Influenza is a communicable disease caused by a virus. Explain how the human body responds to an influenza infection, from the point at which the virus enters the body to the destruction of the pathogen.
Written & reviewed by James Millett — Biology (Imperial College London), PGCE Science (University of Cambridge).
Model answer (5 marks)
1. The virus first encounters the non‑specific barrier of the respiratory tract – mucus, cilia and secreted antibodies – which traps and removes some particles.
2. If the virus penetrates, innate immune cells (macrophages, dendritic cells) recognise viral antigens on its surface.
3. These cells present the antigens to lymphocytes, which activate B‑cells to produce antibodies that are complementary to the viral antigens.
4. The antibodies bind to the virus, neutralising it and causing agglutination, which prevents attachment to host cells.
5. Antibody‑coated viruses are recognised by phagocytes, which engulf and digest them; memory B‑cells remain for a faster response if the virus re‑enters.
2. If the virus penetrates, innate immune cells (macrophages, dendritic cells) recognise viral antigens on its surface.
3. These cells present the antigens to lymphocytes, which activate B‑cells to produce antibodies that are complementary to the viral antigens.
4. The antibodies bind to the virus, neutralising it and causing agglutination, which prevents attachment to host cells.
5. Antibody‑coated viruses are recognised by phagocytes, which engulf and digest them; memory B‑cells remain for a faster response if the virus re‑enters.
Examiner tips
- Use the exact terms: ‘non‑specific barrier’, ‘antigens’, ‘antibodies’, ‘agglutination’, ‘phagocytosis’, ‘memory cells’.
- Sequence the stages logically – barrier → recognition → antibody production → neutralisation → phagocytosis/memory.
- Include both innate and adaptive components to hit all points.
Common mistakes
- Mixing up innate and adaptive responses; e.g., calling antibody production innate.
- Omitting the role of memory cells or phagocytosis.
- Using vague terms like ‘immune response’ instead of specific mechanisms.
Mark scheme (5 marks)
- Non-specific defence / barrier is the first line of defence (e.g. skin, mucus, hairs in the nose, stomach acid)
- White blood cells detect the virus using antigens on its surface
- Lymphocytes produce antibodies that are specific / complementary to the antigens on the influenza virus
- Antibodies bind to antigens on the virus to neutralise / clump (agglutinate) the pathogens together
- Phagocytes engulf and digest the pathogen (phagocytosis) / memory cells remain so future infection is destroyed more quickly
Key terms in this question
Related
- All Eduqas A-Level Biology revision notes →
- How to answer a "Explain" question →
- Decode the mark scheme abbreviations →
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