Explain how the structure of a chemical synapse ensures that neural signals are transmitted in one direction only.
Written & reviewed by James Millett — Biology (Imperial College London), PGCE Science (University of Cambridge).
Model answer (4 marks)
Synaptic vesicles containing neurotransmitter are found only in the presynaptic terminal, so the presynaptic neuron can release the signal.
Receptor proteins (ligand‑gated ion channels) for that neurotransmitter are located only on the postsynaptic membrane, so only the postsynaptic neuron can respond.
When the vesicles fuse, neurotransmitter diffuses across the synaptic cleft and binds to the postsynaptic receptors, generating a postsynaptic potential.
The presynaptic membrane lacks these receptors, so the postsynaptic neuron cannot trigger a signal back into the presynaptic neuron – the signal is therefore unidirectional.
Receptor proteins (ligand‑gated ion channels) for that neurotransmitter are located only on the postsynaptic membrane, so only the postsynaptic neuron can respond.
When the vesicles fuse, neurotransmitter diffuses across the synaptic cleft and binds to the postsynaptic receptors, generating a postsynaptic potential.
The presynaptic membrane lacks these receptors, so the postsynaptic neuron cannot trigger a signal back into the presynaptic neuron – the signal is therefore unidirectional.
Examiner tips
- Mention vesicles only in presynaptic terminal; receptors only postsynaptic; explain diffusion and binding; note absence of receptors on presynaptic side.
- Use the exact terms ‘synaptic vesicles’, ‘ligand‑gated ion channels’, ‘synaptic cleft’ and ‘unidirectional transmission’.
- Keep answer concise – 4 points, one sentence each.
Common mistakes
- Saying that neurotransmitter is released from both sides; forgetting that presynaptic membrane has no receptors; using vague terms like ‘signal’ without specifying vesicles or receptors.
Mark scheme (4 marks)
- Synaptic vesicles containing neurotransmitter are located only in the presynaptic terminal / presynaptic knob
- Receptor proteins / ligand-gated ion channels for the neurotransmitter are located only on the postsynaptic membrane
- Neurotransmitter diffuses across the synaptic cleft and binds to postsynaptic receptors, generating a signal in the postsynaptic neuron
- The presynaptic membrane lacks receptors, so the postsynaptic neuron cannot trigger a signal in the presynaptic neuron / signal cannot travel in reverse
Key terms in this question
Related
- All IB DP Biology Standard Level (2023 syllabus) revision notes →
- How to answer a "Explain" question →
- Decode the mark scheme abbreviations →
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