Explain how the compartmentalisation provided by membrane-bound organelles allows eukaryotic cells to carry out multiple, potentially conflicting, biochemical processes simultaneously.

IB DP Biology Standard Level (2023 syllabus) — B2.2 Organelles and compartmentalisation · Explain · 4 marks · View as Markdown

Written & reviewed by James Millett — Biology (Imperial College London), PGCE Science (University of Cambridge).

Model answer (4 marks)

Membrane‑bound organelles create separate internal compartments, each a distinct micro‑environment that isolates different biochemical reactions from one another.

Each compartment can maintain its own optimal conditions – for example, a low pH and high ion concentration in lysosomes, a high ATP/ADP ratio in mitochondria, or a high concentration of ribosomes in the rough ER – which are tailored to the enzymes and reactions it contains.

By keeping potentially damaging or conflicting reactions apart, the cell prevents interference. For instance, hydrolytic enzymes in lysosomes are isolated from the cytoplasm, so the cell does not digest its own proteins.

Finally, concentrating specific enzymes and substrates within a compartment increases reaction efficiency and rate, allowing multiple pathways to proceed concurrently without competition for substrates.

Examiner tips

  • Use the word ‘compartment’ and mention membranes; link to isolation of reactions and distinct conditions; give a clear example such as lysosomes; explain how concentration boosts efficiency.
  • Structure answer in four clear points matching the mark scheme.

Mark scheme (4 marks)

  1. Membranes create separate internal compartments/microenvironments within the cell, isolating different biochemical reactions from one another.
  2. Each compartment can maintain its own distinct conditions (e.g. pH, ion concentration, redox state) optimised for the enzymes/reactions it contains.
  3. Potentially damaging/conflicting reactions are kept apart, preventing interference — for example, hydrolytic (digestive) enzymes in lysosomes are separated from the rest of the cytoplasm, preventing self-digestion.
  4. Concentrating specific enzymes and substrates within a compartment increases the efficiency/rate of reactions, allowing multiple pathways to proceed concurrently without competition for substrates.

Key terms in this question

compartmentalisation · membrane-bound organelle

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