Describe the role of the sugar molecule in the structure of nucleic acids and Explain how its variation between DNA and RNA affects the function of each type of nucleic acid.

IB DP Biology Higher Level (2023 syllabus) — A1.2 Nucleic acids · Describe, Explain · 4 marks · View as Markdown

Written & reviewed by James Millett — Biology (Imperial College London), PGCE Science (University of Cambridge).

Model answer (4 marks)

The sugar in nucleic acids is a five‑carbon pentose that forms the backbone of the polymer.
1. It links to a phosphate group to give a repeating –5′‑phosphate‑sugar‑3′ chain.
2. In DNA the sugar is deoxyribose (2′‑deoxyribose).
3. In RNA the sugar is ribose (2′‑hydroxyl).
4. The 2′‑hydroxyl in ribose makes RNA more chemically reactive and less stable, allowing it to adopt diverse secondary structures and act as a catalyst or messenger; the absence of the 2′‑OH in deoxyribose gives DNA a more stable, double‑stranded structure suited for long‑term storage of genetic information.

Examiner tips

  • Use the term ‘pentose’ and mention the phosphate linkage; state the specific sugars; explain stability vs reactivity; link structure to function (storage vs messenger).

Common mistakes

  • Confusing deoxyribose with ribose; forgetting the 2′‑OH difference; not linking sugar difference to DNA stability and RNA flexibility.

Mark scheme (4 marks)

  1. description of the role of the sugar molecule in the structure of nucleic acids
  2. identification of the sugar molecule in DNA
  3. identification of the sugar molecule in RNA
  4. explanation of how the variation in sugar molecule affects the function of DNA and RNA

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